Felicity Currie – Curriculum Vitae

Current Position

  • Post Doctoral Research Associate in Microbial Biotechnology: The microbial biogenesis of propane and other industrially important hydrocarbons. School of Biomedical Sciences, Ulster University. 

Research Interests

  • The microbial biogenesis of propane and other industrially important hydrocarbons
  • Untargeted metabolomics and lipidomics studies for biochemical pathway analysis, and for biomarker discovery in infectious disease
  • Untargeted transcriptomics studies for functional pathway analysis

Skills and Expertise

  • Analytical Sciences: I obtained a PhD in Metabolomics from the University of Manchester, where I carried out untargeted metabolomics and lipidomics studies. I have wide experience of analytical chemistry (MS, FTIR, NMR, LC, GC) and in structure determination of novel compounds.
  • Statistical Data Analysis: I have 5+ years’ experience in evaluating complex data from metabolomics experiments, using Matlab and R for statistical analysis of large datasets to identify differentially regulated metabolites.
  • Database Design and Management: I produced the relational database design for the isolation of secondary metabolites at MNL, and managed database content, queries and reports – marketed successfully by White Point Systems (http://whitepointsystems.com/manual/napis_l/index.php).
  • Cheminformatics: I obtained an MSc in Cheminformatics at the University of Sheffield, with modules including bioinformatics, database design, chemical representation, chemical library design, chemical similarity searching and a project undertaken with Barnard Chemical Information (http://www.digitalchemistry.co.uk), comparing performance of standard and dataset-specific fragment dictionaries, and hashed chemical fingerprints.
  • Software / Programming: Matlab, R, Java, SQL  
  • Teaching: NQT in Secondary Science / PGCE (Keele, 2017). Associate Fellow of the HEA (2014). I delivered lectures on Metabolomics for MSc courses at LSTM and I continue to mentor PhD students. I produced learning materials including a toolbox of statistical methods and model data.
  • Team Management & Knowledge Transfer

Education and Qualifications

  • PhD in Metabolomics University of Manchester (2011)  Professor Royston Goodacre

I carried out untargeted metabolomics and lipidomics studies on the abiotic perturbation of Pseudomonas putida

  • MSc in Cheminformatics (Distinction) University of Sheffield (2002)
  • BSc (Hons) in Medicinal & Pharmaceutical Chemistry Loughborough University (1984)
  • Associate Fellowship of the Higher Education Academy (2014)
  • NQT /PGCE Secondary Science OAKS SCITT, Keele University (2017)

Employment History

  • PDRA The microbial biogenesis of propane and other industrially important hydrocarbons Aug 2018 – present
  • Microbiome profiling and metagenomics studies
  • Mining of genomic data for functional analysis
  • Analytical chemistry for the Identification of propane and other hydrocarbons
  • Metabolomics and transcriptomics studies for biochemical pathway analysis
  • Optimization and scale-up for a commercially viable fermentation route to biopropane
  • PDRA Metabolomics for Tuberculosis, Liverpool School of Tropical Medicine May 2012 – May 2015
  • I established the MS and data analysis pipeline for biomarker discovery studies in infectious diseases including Tuberculosis and Malaria
  • Research Associate, Natural Products Chemistry, Xenova & MNL, Aberystwyth, Oct 1989 – Jun 2001
  • Structural elucidation of secondary metabolites isolated from fungi and plants utilising MS and NMR.
  • Knowledge and capability transfer to new laboratories.
  • People management: leading a team in metabolite fingerprinting, compound isolation and QC. 
  • Database design and management.
  • Research Officer, Carbohydrate Research, Laboratory for Molecular Structure, NIBSC, Nov. 1984 – Oct 1989
  • Structural elucidation of complex carbohydrates – components of vaccines and engineered glycoproteins.

Publications

https://www.scopus.com/authid/detail.uri?authorId=24351034500

In preparation:

Felicity Currie, Warwick B. Dunn, David I. Broadhurst, Yun Xu and Royston Goodacre Altered phospholipids in Pseudomonas putida KT2440 UWC1 exposed to propranolol. 

Relevant publications:

1. Felicity Currie, David I. Broadhurst, Warwick B. Dunn, Christopher A. Sellick and Royston Goodacre (2016). Molecular Biosystems 12: 1367-1377

2. Patel SA, Currie F, Thakker N, Goodacre R. (2008). Analyst 133:1707-1713.

3. Morrison N, Bearden D, Bundy JG, Collette T, Currie F, Davey MP, et al. (2007) Metabolomics 3: 203-210.

4. López-Díez E.C., Winder C.L., Ashton, L., Currie F. & Goodacre R. (2005) Analytical Chemistry 77, 2901-2906.

Presentations

Felicity Currie Predict-TB WP3: Enabling Technologies summarising research within IMI Predict-TB to improve preliminary screening for activity against M. tuberculosis. IMI Predict-TB Interim Review, Brussels October 2014

Felicity Currie (University of Manchester) Using metabolomics to reveal the microbial response to pharmaceutical exposure in the environment. Environmental Metabolomics Workshop – Invited Speaker BES Annual Meeting 2008