- Post Doctoral Research Associate in Microbial Biotechnology: The microbial biogenesis of propane and other industrially important hydrocarbons. School of Biomedical Sciences, Ulster University.
- The microbial biogenesis of propane and other industrially important hydrocarbons
- Untargeted metabolomics and lipidomics studies for biochemical pathway analysis, and for biomarker discovery in infectious disease
- Untargeted transcriptomics studies for functional pathway analysis
Skills and Expertise
- Analytical Sciences: I obtained a PhD in Metabolomics from the University of Manchester, where I carried out untargeted metabolomics and lipidomics studies. I have wide experience of analytical chemistry (MS, FTIR, NMR, LC, GC) and in structure determination of novel compounds.
- Statistical Data Analysis: I have 5+ years’ experience in evaluating complex data from metabolomics experiments, using Matlab and R for statistical analysis of large datasets to identify differentially regulated metabolites.
- Database Design and Management: I produced the relational database design for the isolation of secondary metabolites at MNL, and managed database content, queries and reports – marketed successfully by White Point Systems (http://whitepointsystems.com/manual/napis_l/index.php).
- Cheminformatics: I obtained an MSc in Cheminformatics at the University of Sheffield, with modules including bioinformatics, database design, chemical representation, chemical library design, chemical similarity searching and a project undertaken with Barnard Chemical Information (http://www.digitalchemistry.co.uk), comparing performance of standard and dataset-specific fragment dictionaries, and hashed chemical fingerprints.
- Software / Programming: Matlab, R, Java, SQL
- Teaching: NQT in Secondary Science / PGCE (Keele, 2017). Associate Fellow of the HEA (2014). I delivered lectures on Metabolomics for MSc courses at LSTM and I continue to mentor PhD students. I produced learning materials including a toolbox of statistical methods and model data.
- Team Management & Knowledge Transfer
Education and Qualifications
- PhD in Metabolomics University of Manchester (2011) Professor Royston Goodacre
I carried out untargeted metabolomics and lipidomics studies on the abiotic perturbation of Pseudomonas putida.
- MSc in Cheminformatics (Distinction) University of Sheffield (2002)
- BSc (Hons) in Medicinal & Pharmaceutical Chemistry Loughborough University (1984)
- Associate Fellowship of the Higher Education Academy (2014)
- NQT /PGCE Secondary Science OAKS SCITT, Keele University (2017)
- PDRA The microbial biogenesis of propane and other industrially important hydrocarbons Aug 2018 – present
- Microbiome profiling and metagenomics studies
- Mining of genomic data for functional analysis
- Analytical chemistry for the Identification of propane and other hydrocarbons
- Metabolomics and transcriptomics studies for biochemical pathway analysis
- Optimization and scale-up for a commercially viable fermentation route to biopropane
- PDRA Metabolomics for Tuberculosis, Liverpool School of Tropical Medicine May 2012 – May 2015
- I established the MS and data analysis pipeline for biomarker discovery studies in infectious diseases including Tuberculosis and Malaria
- Research Associate, Natural Products Chemistry, Xenova & MNL, Aberystwyth, Oct 1989 – Jun 2001
- Structural elucidation of secondary metabolites isolated from fungi and plants utilising MS and NMR.
- Knowledge and capability transfer to new laboratories.
- People management: leading a team in metabolite fingerprinting, compound isolation and QC.
- Database design and management.
- Research Officer, Carbohydrate Research, Laboratory for Molecular Structure, NIBSC, Nov. 1984 – Oct 1989
- Structural elucidation of complex carbohydrates – components of vaccines and engineered glycoproteins.
Felicity Currie, Warwick B. Dunn, David I. Broadhurst, Yun Xu and Royston Goodacre Altered phospholipids in Pseudomonas putida KT2440 UWC1 exposed to propranolol.
1. Felicity Currie, David I. Broadhurst, Warwick B. Dunn, Christopher A. Sellick and Royston Goodacre (2016). Molecular Biosystems 12: 1367-1377
2. Patel SA, Currie F, Thakker N, Goodacre R. (2008). Analyst 133:1707-1713.
3. Morrison N, Bearden D, Bundy JG, Collette T, Currie F, Davey MP, et al. (2007) Metabolomics 3: 203-210.
4. López-Díez E.C., Winder C.L., Ashton, L., Currie F. & Goodacre R. (2005) Analytical Chemistry 77, 2901-2906.
Felicity Currie Predict-TB WP3: Enabling Technologies summarising research within IMI Predict-TB to improve preliminary screening for activity against M. tuberculosis. IMI Predict-TB Interim Review, Brussels October 2014
Felicity Currie (University of Manchester) Using metabolomics to reveal the microbial response to pharmaceutical exposure in the environment. Environmental Metabolomics Workshop – Invited Speaker BES Annual Meeting 2008